Relationship Between Breast Cancer Parameters and miR-195 and miRNA206 Expression: A Study in Women in Iraq

Uncontrolled cell proliferation is a hallmark of breast cancer (BC), a malignant disease that frequently results in the development of tumors. With distinct genetic profiles and clinical consequences, it has multiple molecular subtypes, such as triple-negative, HER2-positive, luminal A, and luminal B. This study investigated the relationship between the expression of the microRNAs miR-195 and miR-206 in a sample of female BC patients from Iraq and their illness features and demographic distribution. Most BC cases occur in women between the ages of 40 and 59. The study included 60 patients and 60 healthy women. There were no appreciable variations between the right and left breast placements, and the average age of BC patients was 49.27 ± 10.66. Luminal A was the most prevalent molecular subtype of invasive ductal carcinoma (IDC), which was the most prevalent kind overall. The highest rates of BC were found in stages II and III, at 40% and 36%, respectively. While there were no discernible changes between the luminal a, luminal B, and HER2 subtypes, RT-qPCR using miR-16 as an internal reference revealed that miR-195 was markedly increased in BC patients relative to controls. With no discernible variations between molecular subtypes, miR-206 was downregulated in BC patients; however, it was significantly downregulated in stages II, III, and IV in comparison to stage I. These results imply that miR-195 and miR-206 might be involved in the onset and development of BC.