Engineered commensals for targeted nose-to-brain drug delivery

Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.

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Publication Details

Journal
Singapore Institute of Technology
Published
2025-01-01
DOI
https://doi.org/10.25447/sit.29890241.v1
Primary Topic
Ecology and biodiversity studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Engineered commensals for targeted nose-to-brain drug delivery

Singapore Institute of Technology
Ecology and biodiversity studies
article

Engineered commensals for targeted nose-to-brain drug delivery

article en

Abstract

Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.

Singapore Institute of Technology
Singapore Institute of Technology (SG), University Health System (US), National University Health System (SG)
Good health and well-being
Openalex Percentile: Top 50%
Ecology and biodiversity studies
DOIOpen Access PDFOpenAlex
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Engineered commensals for targeted nose-to-brain drug delivery · Singapore Institute of Technology (2025) | TGRS Research Map | TGRS