Simulation of Multi-Coil Single-Sided MPI System with Offset Field Spatial Encoding

Single-sided Magnetic particle imaging (MPI) systems have great potential for clinical applications because it concentrates all hardware on one side, allowing for an unrestricted imaging volume. However, the non-uniform magnetic field distribution in single-sided MPI devices poses challenges for generating high gradient selection fields. To address this, we developed a new offset field spatial encoding technique that combines amplitude modulation technology within a multi-coil structure, enabling 3D imaging without the need for classical selection fields and mechanical movement scanning. In simulation experiments, we validated the feasibility of this design, and the results indicate that the single-sided MPI device based on multi-coil amplitude modulation technology has the potential to achieve high spatial resolution and high temporal resolution.