Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study
Simulation results datasets. adapt_simulations.RDS is the dataset of simulated trial results for the adaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) nonadapt_simulations.RDS is the dataset of simulated trial results for the nonadaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) seed_sensitivity.RDS and prior_sensitivity.RDS are the dataset of simulated trial results for the sensitivity analyses using a different seed and prior, respectively. latestart_simulations.RDS is the dataset of simulated trial results for the 2 interim trials with the first interim occurring 75% through the trial. adapt_newscen.RDS and nonadapt_newscen.RDS are the simulated trial results for the less clear optimal arm scenarios.
Publication Details
- Journal
- OSF Preprints (OSF Preprints)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.17605/osf.io/kj7yf
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00