Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study

Simulation results datasets. adapt_simulations.RDS is the dataset of simulated trial results for the adaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) nonadapt_simulations.RDS is the dataset of simulated trial results for the nonadaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) seed_sensitivity.RDS and prior_sensitivity.RDS are the dataset of simulated trial results for the sensitivity analyses using a different seed and prior, respectively. latestart_simulations.RDS is the dataset of simulated trial results for the 2 interim trials with the first interim occurring 75% through the trial. adapt_newscen.RDS and nonadapt_newscen.RDS are the simulated trial results for the less clear optimal arm scenarios.

Publication Details

Journal
OSF Preprints (OSF Preprints)
Published
2025-01-01
DOI
https://doi.org/10.17605/osf.io/kj7yf
Primary Topic
Statistical Methods in Clinical Trials
Type
article
Field-Weighted Citation Impact
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article

Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study

OSF Preprints (OSF Preprints)
Statistical Methods in Clinical Trials
article

Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study

article en

Abstract

Simulation results datasets. adapt_simulations.RDS is the dataset of simulated trial results for the adaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) nonadapt_simulations.RDS is the dataset of simulated trial results for the nonadaptive trials. (k15 = 15 clusters per arm, k25 = 25 clusters per arm) seed_sensitivity.RDS and prior_sensitivity.RDS are the dataset of simulated trial results for the sensitivity analyses using a different seed and prior, respectively. latestart_simulations.RDS is the dataset of simulated trial results for the 2 interim trials with the first interim occurring 75% through the trial. adapt_newscen.RDS and nonadapt_newscen.RDS are the simulated trial results for the less clear optimal arm scenarios.

OSF Preprints (OSF Preprints)
Openalex Percentile: Top 48%
Statistical Methods in Clinical Trials
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