Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary

This report reviews over 25 systematic reviews and meta-analyses (2020–2024) on ketamine-based treatments for depression. It compares the efficacy and speed of IV ketamine, esketamine nasal spray (Spravato), and oral ketamine. It also examines emerging data on ketamine-assisted psychotherapy. The goal is to provide patients, clinicians, and researchers with clear, evidence-based insights on real-world remission rates, onset times, and treatment reliability across methods.

Publication Details

Journal
Open Science Framework
Published
2025-01-01
DOI
https://doi.org/10.17605/osf.io/4bqds
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00
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article

Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary

Open Science Framework
Treatment of Major Depression
article

Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary

article en

Abstract

This report reviews over 25 systematic reviews and meta-analyses (2020–2024) on ketamine-based treatments for depression. It compares the efficacy and speed of IV ketamine, esketamine nasal spray (Spravato), and oral ketamine. It also examines emerging data on ketamine-assisted psychotherapy. The goal is to provide patients, clinicians, and researchers with clear, evidence-based insights on real-world remission rates, onset times, and treatment reliability across methods.

Open Science Framework
Good health and well-being
Openalex Percentile: Top 44%
Treatment of Major Depression
DOIOpen Access PDFOpenAlex
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Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary · Open Science Framework (2025) | TGRS Research Map | TGRS