Medications and individual factors associated with serotonin syndrome: a protocol for an overview of reviews

Serotonin syndrome is a potentially lethal adverse drug reaction caused by exposure to one or more serotonin-elevating medications. Its burden is unknown due to the absence of official diagnostic criteria, under-reporting and symptom overlap with other syndromes. This overview of reviews aims to summarise published systematic review evidence on drugs and risk factors commonly associated with serotonin syndrome and to determine its incidence.