Advance of circRNA in the research on orthopedic diseases

Circular RNAs(circRNAs) are a class of closed-loop non-coding RNAs(ncRNAs) formed by head-to-tail covalent bonds. CircRNAs participate in the development of osteoarthritis by regulating extracellular matrix degradation, inflammatory response and homeostasis of chondrocytes; It regulates the osteogenic differentiation of bone marrow mesenchymal stem cells, the activity of bone microvascular endothelial cells and angiogenesis to affect femoral head necrosis; It regulates the differentiation of bone marrow stem cells, osteoblasts and osteoclasts to cause osteoporosis and it affects the invasion, metastasis and drug resistance of osteosarcoma through different pathogenesis. CircRNAs are expected to become a new clinical diagnostic marker in the future.