Oxidative stress and neuroregenerative processes – pathophysiological correlations and new pharmacotherapeutic approaches in the treatment of neuroregenerative diseases

<p>The aims of the current study are estimation of the correlations between oxidative stress and neuroregenerative processes and new pharmacotherapeutic approaches in the treatment of Parkinsonism. The investigation has been made through the existing electronical database of medical sources. Oxidative stress arises from an increased production of reactive oxygen/nitrogen species (ROS/RNS) or from a failure of the body's antioxidant defenses, characterized by a reduced ability of endogenous systems to combat the oxidative attack directed at target biomolecules. It is broadly defined as a lack of balance between the levels of reactive oxygen/nitrogen species (ROS/RNS) and the body's ability to counteract their effect through antioxidant defence systems. Free-radical induced attack has been associated with the onset of numerous health conditions such as neurodegenerative diseases (Parkinson's, Alzheimer's, Huntington's and amyotrophic lateral sclerosis), cardiovascular and inflammatory diseases. In addition, the irreversible progression of oxidative deposition caused by reactive oxygen species (ROS) leads to accelerated biological aging, blocked biological functions, and overall. Other risk factors for neuroregenerative processes are glutamate toxicity, autoimmune, protein aggregation, inflammation. The most severe motor neuron degenerative illness is Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disorder).</p>