Association of KGs with immune cells in ccRCC.

<p><b>S1 Table.</b> The gene expression profile datasets that were analyzed in this study. <b>S2 Table.</b> Collection of ccRCC related candidate drug agents from published articles and other sources. <b>S3 Table.</b> Collection of proposed key genes from published articles. <b>S4 Table</b>. List of upregulated and downregulated common DEGs (cDEGs) of ccRCC in 9 datasets (GSE16441, GSE53757, GSE66270, GSE66272, GSE16449, GSE76351, GSE66271, GSE71963 and GSE36895). <b>S5 Table.</b> List of screened cDEGs (scDEGs) from cDEGs through survival analysis. <b>S6 Table.</b> List of key genes (KGs) from PPI network based on different topological measures. <b>S7 Table.</b> Pan-cancer analysis of KGs. <b>S8Table.</b> Docking/ (binding affinity) scores (kcal/mol) between the proposed target genes/proteins (receptors) and top ordered 50 candidate drugs (out of 327). <b>S9 Table.</b> Docking/ (binding affinity) scores (kcal/mol) between the proposed drugs and 30 independent receptors(published). <b>S10 Table.</b> The 3-dimension view of strong binding interactions between targets and drugs. <b>S11 Table.</b> Drug-likeness profile of top-ranked ten drugs.</p> <p>(DOCX)</p>

Publication Details

Journal
Figshare
Published
2024-09-30
DOI
https://doi.org/10.1371/journal.pone.0310843.s001
Primary Topic
Ferroptosis and cancer prognosis
Type
article
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article

Association of KGs with immune cells in ccRCC.

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Ferroptosis and cancer prognosis
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Association of KGs with immune cells in ccRCC.

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Abstract

<p><b>S1 Table.</b> The gene expression profile datasets that were analyzed in this study. <b>S2 Table.</b> Collection of ccRCC related candidate drug agents from published articles and other sources. <b>S3 Table.</b> Collection of proposed key genes from published articles. <b>S4 Table</b>. List of upregulated and downregulated common DEGs (cDEGs) of ccRCC in 9 datasets (GSE16441, GSE53757, GSE66270, GSE66272, GSE16449, GSE76351, GSE66271, GSE71963 and GSE36895). <b>S5 Table.</b> List of screened cDEGs (scDEGs) from cDEGs through survival analysis. <b>S6 Table.</b> List of key genes (KGs) from PPI network based on different topological measures. <b>S7 Table.</b> Pan-cancer analysis of KGs. <b>S8Table.</b> Docking/ (binding affinity) scores (kcal/mol) between the proposed target genes/proteins (receptors) and top ordered 50 candidate drugs (out of 327). <b>S9 Table.</b> Docking/ (binding affinity) scores (kcal/mol) between the proposed drugs and 30 independent receptors(published). <b>S10 Table.</b> The 3-dimension view of strong binding interactions between targets and drugs. <b>S11 Table.</b> Drug-likeness profile of top-ranked ten drugs.</p> <p>(DOCX)</p>

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