Relative percentage of intact FGF23 to C-terminal FGF23.

<p>Relative percentage of intact FGF23 relative to C-terminal FGF23 in serum. (A) C57BL/6J male mice were fed a diet containing 0.6% inorganic phosphorus (Pi), 1.2% Pi, or 1.65% Pi for 2 weeks. (B) Eight-week-old male mice were fed a diet containing 0.02% or 0.6% inorganic phosphorus (LP) for 2 weeks. (C) Eight-week-old male mice carrying a mutation in the Phex gene (hyp mice) compared to age and sex matched wild-type littermates (control). Data are represented as mean ± SD. All data were analyzed for normality with Shapiro-Wilk test, homogeneity of variance by F test. Samples were in normal distribution and equal variance. One-way ANOVA with Dunnett’s multiple comparison test was performed (A), or unpaired t test was performed compared to WT (B, C). <i>*P</i> <0.05, <i>****P</i> <0.0001 compared to CONT (control diet).</p> <p>(PDF)</p>