Analysis of epidermal NHEM scRNA-seq data taken from EGAS00001002927 and mouse hair follicle data set (GSE147299) (related to Figs 1 and 4, respectively).

<p>(A) UMAP visualisation of the human skin melanocyte coloured by the clusters. (B) Dot plot of depicting the top 10 marker genes enriched in each cluster with size showing the percent cells expressing the gene and colour depicting the scaled mean expression value in each cluster (Wilcoxon–Mann–Whitney test with average log fold change > 0.25 and adjusted <i>p</i>-value ≤0.05). (C) Dot plot depicting top 5 GO terms enriched in each cluster identified using cluster markers. (D) Heat map depicting the gene-set activity scores (z-score of mean) of each of the epidermal NHEM clusters for the human melanocyte mature, proliferative, IFN enriched, and stem-like state. (E) Heatmap depicting the scores (z-score of mean) of each of the B16 clusters for the mouse hair follicle melanocyte mature, proliferative and stem-like state. All numerical data are listed in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002776#pbio.3002776.s011" target="_blank">S1 Data</a>.</p> <p>(DOCX)</p>