List of biochemical reactions for CSL312 and ecallantide (DX88).

<p>Surface-bound species indicated by a subscript ‘s’. It is important to note that the binding affinity of CSL312 to FXII zymogen, as measured in-house via surface plasmon resonance (SPR), may not be accurate. This uncertainty primarily arises from challenges in obtaining pure FXII zymogen. The presence of small amounts of FXIIa, known to have a significantly higher affinity for CSL312, may result in an overestimation of the zymogen binding affinity. To assess the impact of this uncertainty on BK inhibition, we conducted simulations using an order of magnitude lower affinity of CSL312 for the FXII zymogen. The results indicated a negligible difference in BK generation levels.</p> <p>(PDF)</p>