<i>DRB1*15</i>:<i>01-DQB1*06</i>:<i>02</i> protection in T1D is enhanced amongst individuals with a low iKIR score.

<p>The cohort was stratified into individuals with high or low iKIR score using different iKIR score thresholds (1.5, 1.75, 2.0 and 2.5). The protective effect of <i>DRB1*15</i>:<i>01-DQB1*06</i>:<i>02</i> was evaluated independently in each stratum using multivariate logistic regression with gender included as a covariate. <i>DRB1*15</i>:<i>01-DQB1*06</i>:<i>02</i> is significantly protective (ln[OR] = –3.9, P = 1.14×10<sup>−165</sup>) in the cohort (Group = Whole cohort, unstratified analysis). Regression coefficients, p-values and cohort sizes are reported for the different strata. P-value for the unstratified analysis calculated using Wald-test; all other p-values calculated using a permutation test.</p> <p>(PDF)</p>