Enriched RBP-binding sites and characteristics of subsets of FLEXIs with a binding site for each of the RBPs in Clusters I-VI.

<p>Scatter plots and density plots are shown for FLEXIs with binding sites for each protein in (A) Cluster I, (B) Cluster II, (C) Cluster III, (D) Cluster IV, (E) Cluster V, and (F) Cluster VI. In the scatter plots (left), RBPs whose binding sites were significantly over- or under-represented compared to those for other RBPs in the subset of FLEXIs compared to all other FLEXIs (≥2% abundance, p≤0.05 calculated by Fisher’s exact test and adjusted by the Benjamini-Hochberg procedure) are labeled by name color coded by protein function as shown at the bottom of the Figure. The density distribution plots (right) compare the length, GC content, and MFE for the most stable secondary structure predicted by RNAfold for subsets of FLEXIs with binding sites for each RBP associated with Clusters I to VI (red) compared to all other FLEXIs (black). The number of FLEXIs comprising each subset is indicated in parentheses next to the name of the RBP. p-values are shown at the top left of those density plots in which the distribution for the subset of FLEXIs differed significantly from other FLEXIs (p<0.01 and FDR≤0.05 as determined by 1,000 Monte-Carlo simulations).</p> <p>(PDF)</p>