Full-Field Electroretinogram (ffERG) did not detect significant changes in retinal or retino-cortical function over the course of the studies.

<p>Representative ffERG data acquired under dark adaptation (scotopic series) and light adaptation (photopic series), Oscillatory potentials (OPs) data, 30.3-Hz flicker ERG amplitude and timing data and 5.0-Hz flash visual evoked potentials (FVEP) amplitude data from NHP Cy0407 are presented. Rod-mediated and cone-mediated A- and B-waves exhibited normal increases with flash strength, consistent with preserved outer (photoreceptors) and inner (bipolar cells; Müller cells) function. Generally, lower amplitudes were elicited following the first test, but scotopic and photopic ERG amplitudes remained relatively constant for the remainder of the study for all 3 animals. No instances of ‘flat’ or extinguished ERGs were noted. OPs amplitude, 30-Hz flicker ERG amplitude and timing and FVEP amplitude were unaltered across the course of the studies. No clear or consistent evidence of physiologically significant changes in retinal or retino-cortical function were evident in any of the 3 NHPs tested.</p> <p>(PDF)</p>