Voltage response of the point dendrite with excitatory and inhibitory inputs.

<p>Top 2 plots: Example dendrite V<sub>m</sub> traces for different orientations, as in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002935#pbio.3002935.s004" target="_blank">S1 Fig</a>, when GABA<sub>A</sub> synapses (0.2 synapses/μm density) were randomly stimulated with mean Poisson frequency 10 Hz. Following plots show example dendrite V<sub>m</sub> traces for target orientation with increasing the inhibitory conductance and mean Poisson frequency of inhibitory activation. In each subplot with gray are voltage responses from 10 repetitions, and in teal is the mean response. The colored segments in the inset show the impact of the <i>E</i><sub>K</sub><sup>+</sup> shift (comparison of the first and third responses). As in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002935#pbio.3002935.s004" target="_blank">S1 Fig</a>, the first stimulation event induces a small <i>E</i><sub>K</sub><sup>+</sup> shift (10 mV) for the target orientation. High <i>E</i><sub>K</sub><sup>+</sup> shifts increase dendritic spike occurrence and dendritic spike duration in the presence of nonspecific inhibition. High enough inhibition (bottom panel) reduces dendritic spike occurrence irrespective of the <i>E</i><sub>K</sub><sup>+</sup> shift.</p> <p>(PDF)</p>