Iodine(III)-Mediated\nKeto-oximation of <i>O</i>‑Alkynyl Hydroxylamines:\nA Route to 3‑Acyl Isoxazolines\nand 1,2-Oxazines

An intramolecular iodine(III)-mediated\nketo-oximation\nof <i>O</i>-alkynyl hydroxylamines offers rapid and straightforward\naccess to 3-acyl Δ<sup>2</sup>-isoxazolines and 1,2-oxazines.\nThis approach features mild, metal-free, and aerobic reaction conditions\nwith good functional group tolerance. Moreover, the synthetic utility\nof this method is demonstrated by the synthesis of unique structural\nmotifs such as isoxazolidine, 3-vinyl isoxazoline, and 2,5-diphenylpyrazine\nderivatives by the conversion of 3-acyl Δ<sup>2</sup>-isoxazolines,\nthereby showcasing its efficiency and applicability in synthetic chemistry.