Palladium-CatalyzedSonogashira Cross-Couplings of(Hetero)Aryl Fluorosulfates

The palladium-catalyzed Sonogashira cross-coupling of (hetero)aryl fluorosulfates and terminal alkynes, featuring a synthetically useful scope and yields, is reported herein. Such transformations involving a diversity of (hetero)aryl fluorosulfate coupling partners, including chemoselective examples where contending chloro functionalities are present, are achieved using a DPPF/[Pd(cinnamyl)Cl]₂ catalyst system without the requirement of a copper additive.