Model-Based\nScale-Up of a Homogeneously Catalyzed\nSonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor

The model-based scale-up\nof a homogeneously catalyzed Sonogashira\ncoupling reaction is performed in a 3D printed metal continuous-flow\nreactor. The reaction is monitored with inline Raman spectroscopy\nwith a low calibration effort, applying a multivariate curve resolution\napproach. Manufacturing conditions result in a space time yield of\n412 kg m<sup>–3</sup> h<sup>–1</sup> and a productivity\nrate of 0.078 kg h<sup>–1</sup>.

Publication Details

Journal
Figshare
Published
2024-11-27
DOI
https://doi.org/10.1021/acsengineeringau.4c00027.s001
Primary Topic
Pasture and Agricultural Systems
Type
article
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article

Model-Based\nScale-Up of a Homogeneously Catalyzed\nSonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor

Figshare
Pasture and Agricultural Systems
article

Model-Based\nScale-Up of a Homogeneously Catalyzed\nSonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor

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Abstract

The model-based scale-up\nof a homogeneously catalyzed Sonogashira\ncoupling reaction is performed in a 3D printed metal continuous-flow\nreactor. The reaction is monitored with inline Raman spectroscopy\nwith a low calibration effort, applying a multivariate curve resolution\napproach. Manufacturing conditions result in a space time yield of\n412 kg m<sup>–3</sup> h<sup>–1</sup> and a productivity\nrate of 0.078 kg h<sup>–1</sup>.

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Openalex Percentile: Top 34%
Pasture and Agricultural Systems
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Model-Based\nScale-Up of a Homogeneously Catalyzed\nSonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor · Figshare (2024) | TGRS Research Map | TGRS