Ag(I)-Mediated Site-Selective\nC(sp<sup>2</sup>)‑H\nChalcogenation of Tryptophan-Peptides with Dichalcogenides at Room\nTemperature

This report presents a silver-mediated site-selective\nchalcogenation\nof tryptophan-containing peptides with various dichalcogenides (disulfides/diselenides)\nat room temperature in good to excellent yields. The significant features\ninclude broad substrate scope, functional group diversity, late-stage\nmodification of drug molecules (Dopamine and Levodopa), and various\nvaluable postsynthetic transformations under mild conditions.