Nonconventional Luminogens\nBased on Poly(methyl vinyl\nether maleic anhydride) and 4‑(2-Aminoethyl)morpholine for\nMg<sup>2+</sup> Detection and Targeting Lysosomes

Compared with traditional luminescent materials, nonconventional\nluminogens have been extensively studied due to their unique properties\nand wide range of applications. However, the study of nonconventional\nluminescent polymers is rare because most luminescent polymeric materials\ncan only emit light at high concentrations and require noble metal\ncatalysts for synthesis. Particularly, their application in the field\nof metal ion detection and biological imaging is still restricted.\nTo expand its application scope, this work designed a series of luminescent\npolymeric materials only containing carboxyl and amide groups, which\nwere synthesized from poly(methyl vinyl ether maleic anhydride) and\n4-(2-aminoethyl)morpholine at different molar ratios (PMVEMA/AML are\n1:1, 1:2, and 1:3). The synthesized luminogens exhibited controllable\nluminescence colors and excellent solubility in various commonly used\nsolvents. Additionally, the polymers can achieve luminescence in dilute\nsolutions, and the maximal luminescence efficiencies can be up to\n5.55%. At last, polymer M3 with good biocompatibility and low cytotoxicity\ncan be used to sensitively detect Mg<sup>2+</sup> ions in vivo and\nin vitro. Notably, polymer M3 possesses the ability to target the\norganelle lysosome in cell imaging.