Intermolecular Oxidopyrylium\n(5 + 2) Cycloaddition/Reductive\nRing-Opening Strategy for the Synthesis of α‑Methoxytropones

α-Methoxytropone is a structural motif found in\nvarious natural\nproducts and other compounds of interest to the scientific community\nbut remains a synthetic challenge. The present Note describes the\nsynthesis of variously substituted α-methoxytropones and related\ncompounds through an intermolecular 3-hydroxy-4-pyrone-based oxidopyrylium\n(5 + 2) cycloaddition followed by a samarium iodide-mediated reductive\nring-opening. The strategy is highlighted in the synthesis of a novel\nAC-ring analogue of colchicine to compare it to existing methods.