Regio- and Enantioselective\nNickel-Catalyzed Ipso-\nand Remote Hydroamination Utilizing Organic Azides as Amino Sources\nfor the Synthesis of Primary Amines

Primary amines serve as key synthetic precursors to most\nother <i>N</i>-containing compounds, which are important\nin organic \nand medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso-\nand remote hydroamination technique that utilizes organic azides as\ndeprotectable primary amine sources. This strategy offers a highly\nflexible platform for the efficient construction of α-chiral\nbranched primary amines, as well as linear primary amines.