Cu-Catalyzed\nAsymmetric Synthesis of γ‑Amino\nAlcohols Featuring Tertiary Carbon Stereocenters

Alkyne-functionalized oxetanes are presented as versatile\nsubstrates\nthat in combination with amine reagents can be transformed into structurally\ndiverse, chiral γ-amino alcohols featuring a tetrasubstituted\ntertiary stereocenter under Cu catalysis. Control experiments demonstrate\nthe privileged nature of these oxetane precursors in terms of yield\nand asymmetric induction levels in the developed protocol, and postsynthetic\nmodifications offer an easy way to access more advanced synthons.