Multifunctional Polymeric Bioactive Coatings on TiImplants through the Drug Delivery Approach: <i>In Vitro</i> Corrosion Resistance, Biocompatibility, and Antibacterial Characteristics

In the current study, we developed a controlled drug delivery system using a polymeric matrix composed of biopolymer poly(vinylidene fluoride) (PVDF) and ciprofloxacin (CPF)-loaded titanium (Ti) nanotubes (TNTs) on Ti substrates for biomedical applications. The TNT arrays over the Ti surface were obtained through an anodization route. The PVDF coatings were dip-coated on TNT-Ti loaded with CPF. The chemical, microstructure, and surface properties of the TNTs and coated surfaces were characterized using FTIR, XRD, transmission electron microscopy (TEM), scanning electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDS), and surface hydrophilicity analyses. The performance of the implant surfaces was evaluated through <i>in vitro</i> corrosion studies in simulated body fluid (SBF), biocompatibility with MG63 cells, and antibacterial properties. The results revealed that the PVDF/0.1CPF coatings exhibited sustained release of CPF from the polymer matrix at a linear rate and releasing profile for 168 h. PVDF/0.1CPF coating showed decreased corrosion current density (4.457 × 10^–9 A/cm²) by 2 orders of magnitude than that of the Ti substrate, indicating enhanced corrosion protection in the SBF. PVDF/0.1CPF coating showed an antibacterial efficacy of 84.44% against Escherichia coli and 88.33% against Bacillus licheniformis after 24 h. The biocompatibility result showed that after 5 days of culturing, the PVDF/0.1CPF was pointedly higher than that of the pure PVDF and uncoated specimens. Additionally, after 7 days of culture, the quantity of cells on the PVDF/0.1CPF coating continued to increase significantly, whereas the bare specimens and pristine PVDF showed a lower rate of proliferation. The proposed biocompatible polymeric coatings hold synergic antibacterial and corrosion-resistant potential for biomedical applications.