Three-Step Continuous\nFlow Synthesis of the Intermediate\n4‑Fluoro-2-methoxy-5-nitrophenol of Linzagolix

4-Fluoro-2-methoxy-5-nitrophenol is a key intermediate\nof the GnRH\nreceptor antagonist Linzagolix. The traditional synthetic methods\nhave several disadvantages including prolonged reaction time and safety\nissues. Herein, we describe a three-step continuous flow synthesis\nof 4-fluoro-2-methoxy-5-nitrophenol via esterification, nitration,\nand hydrolysis. The total residence time was 234 s, and the total\nyield was 85.6%, which substantially reduced the reaction time and\nconsiderably improved the process safety as well as the total yield.