Cs<sub>2</sub>CO<sub>3</sub>‑Mediated Annulationof Cyclopropane-1,1-dicarbonitriles with <i>o</i>‑Benzenediamines:Access to Substituted 2‑Aminoquinoxalines

The Cs<sub>2</sub>CO<sub>3</sub>-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D–A cyclopropanes and <i>o</i>-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.

Publication Details

Journal
Figshare
Published
2025-03-28
DOI
https://doi.org/10.1021/acs.joc.4c03160.s001
Primary Topic
Cyclopropane Reaction Mechanisms
Type
article
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article

Cs2CO3‑Mediated Annulationof Cyclopropane-1,1-dicarbonitriles with o‑Benzenediamines:Access to Substituted 2‑Aminoquinoxalines

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Cyclopropane Reaction Mechanisms
article

Cs2CO3‑Mediated Annulationof Cyclopropane-1,1-dicarbonitriles with o‑Benzenediamines:Access to Substituted 2‑Aminoquinoxalines

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Abstract

The Cs<sub>2</sub>CO<sub>3</sub>-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D–A cyclopropanes and <i>o</i>-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.

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Openalex Percentile: Top 51%
Cyclopropane Reaction Mechanisms
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Cs<sub>2</sub>CO<sub>3</sub>‑Mediated Annulationof Cyclopropane-1,1-dicarbonitriles with <i>o</i>‑Benzenediamines:Access to Substituted 2‑Aminoquinoxalines · Figshare (2025) | TGRS Research Map | TGRS