Visible-Light-Mediated\nThree-Component Decarboxylative\nCoupling Reactions for the Synthesis of 4‑Alkylpyridines

4-Alkylation of pyridines has been achieved by a photocatalyzed\nthree-component reaction of an olefin, an aryloxyacetic acid, and\ncyanopyridine using Ir[dF(CF<sub>3</sub>)ppy]<sub>2</sub>(dtbbpy)PF<sub>6</sub> as a photocatalyst. In this way, a new type of 4-alkylpyridines\nbearing aryl and aryloxy substituents on the phenyl was accessed with\npotential pharmaceutical value. In addition to mild reaction conditions,\nthe method has several other advantages, including a multicomponent\none-pot protocol, good functional group tolerance, and easy amplification\nof the reaction scale. The reaction mechanism has been clarified by\ncontrol experiments and computation of the reaction energy profile.