Fabrication of Engineered Drug–Polymer Composite\nParticles via Piezoelectric Inkjet Technique for Floating Drug Delivery\nSystems

This\nstudy presents a simple approach for fabricating low-density\ndrug–polymer amorphous solid dispersions (ASDs) using a piezoelectric\ninkjet method, demonstrating potential applications for floating drug\ndelivery systems (FDDS). By adjusting the ratio of two polymers, polylactic\nacid, and Eudragit RLPO, the floatability and drug release rate of\nthe drug–polymer ASD particles can be easily manipulated. Kinetic\nmodel analyses have been conducted to interpret the drug release mechanism.\nThis work offers a robust platform for exploring diverse polymer–drug\ncombinations that are applicable to FDDS.