Biocompatible Acellular\nDermal Matrix-Based Neuromorphic\nDevice with Ultralow Voltage, Ion Channel Emulation, and Synaptic\nForgetting Visualization Computation

Neuromorphic bioelectronics aim to integrate electronics\nwith biological\nsystems yet encounter challenges in biocompatibility, operating voltages,\npower consumption, and stability. This study presents biocompatible\nneuromorphic devices fabricated from acellular dermal matrix (ADM)\nderived from porcine dermis using low-temperature supercritical CO<sub>2</sub> extraction. The ADM preserves the natural scaffold structure\nof collagen and minimizes immunogenicity by eliminating cells, fats,\nand noncollagenous impurities, ensuring excellent biocompatibility.\nThe ADM-based devices emulate biological ion channels with biphasic\nmembrane current modulation, exhibiting temperature dependency and\npH sensitivity. It operates at an ultralow voltage of 1 mV and demonstrates\nreliable synaptic modulation exceeding 4 × 10<sup>4</sup> endurance\ncycles. The activation voltage can be theoretically as low as 59 μV,\ncomparable to brainwave signals with a power of merely 7 aJ/event.\nFurthermore, a brain-like forgetting visualization algorithm is developed,\nleveraging the synaptic forgetting plasticity of ADM-based devices\nto achieve complex computing tasks in a highly energy-efficient manner.\nNeuromorphic devices based on ADM not only hold potential in implantable\nbiointerfaces due to their exceptional biocompatibility, ultralow\nvoltage, and power but also provide a feasible way for energy-efficient\ncomputing paradigms through a synergistic hardware-software approach.