Iron-Catalyzed Perfluoroalkylarylation of Styrenes\nwith Arenes and Alkyl Iodides Enabled by Halogen Atom Transfer

A new iron-catalyzed three-component\nperfluoroalkylarylation of\nstyrenes with alkyl halides and arenes has been established. Alkyl\nhalides undergo halogen atom transfer with methyl radicals to form\nalkyl radicals in reactions initiated by a combination of <i>tert</i>-butyl peroxybenzoate and an iron catalyst, thus adducting\nto the olefins, which results in alkylarylation products. The protocol\nis compatible with a wide range of perfluoroalkyl and non-perfluoroalkyl\nhalides, features excellent functional group tolerance, and enables\nthe synthesis of structurally diverse 1,1-diaryl fluoro-substituted\nalkanes.