Amine-Borane-Mediated,\nNickel/Photoredox-Catalyzed\nCross-Electrophile Coupling between Alkyl and Aryl Bromides

Nickel/photoredox catalysis has emerged as a powerful\nplatform\nfor exploring nontraditional and challenging cross-couplings. Herein,\na metallaphotoredox catalytic protocol has been developed on the basis\nof a tertiary amine-ligated boryl radical-induced halogen atom transfer\nprocess under blue-light irradiation. A wide variety of aryl and heteroaryl\nbromides featuring different functional groups and pharmaceutical\nmoieties were facilely coupled to rapidly install C(sp<sup>3</sup>)-enriched aromatic scaffolds. The compatibility of Lewis base-ligated\nborane with nickel catalysis was well exemplified to extend the chemical\nspace for Ni-catalyzed cross-electrophile coupling.