One-Pot Stereospecific\nSynthesis of 1,4-Oligosaccharides\nby Glycal-Derived Vinyl Epoxides Assembly

Recently, naturally\noccurring linear 1,4-glycans have attracted\nremarkable attention for their activity in cancer and neurodegenerative\ndisease treatment. Classical chemical synthetic strategies for linear\n1,4-oligosaccharides are considerably time-consuming due to orthogonal\nprotection/deprotection, the introduction of leaving groups, and various\nforms of activation of the glycosylation reaction. Herein, we present\na new one-pot microwave-activated reiterative assembly of glycal-derived\nvinyl epoxides in an uncatalyzed substrate-dependent stereospecific\nprocess for the preparation of both β-1,4-d-Gulo and\nα-1,4-d-Manno oligosaccharides.