Natural\nPhycocyanin/Paclitaxel Micelle Delivery of\nTherapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast\nCancer Therapy

The <i>P53</i> gene is commonly mutated in\nbreast cancer,\nprotein based the gene as anticancer drugs could provide efficient\nand stable advantages by restoring the function of the wild-type P53\nprotein. In this study, we describe the creation and utilization of\na micelle composed by natural phycocyanin and paclitaxel and grafting\nanti-HER2 (PPH), which effectively packages and transports recombinant\nP53 protein with anti-ER (PE), resulting in a new entity designated\nas PE@PPH, to address localization obstacles and modify cellular tropism\nto the cell membrane or nucleus. The results indicate that PE@PPH\nhas strong antitumor properties, even at low doses of PTX both <i>in vitro</i> and <i>in vivo</i>. These findings suggest\nthat PE@PPH could be an enhancing micelle for delivering therapeutic\nproteins and promoting protein functional recovery, particularly in\naddressing the challenges posed by tumor heterogeneity in breast cancer.