AlstolarsinesA–E, Indoline Alkaloids withTwo Different Carbon Skeletons from <i>Alstonia scholaris</i>

Five complex indoline alkaloids, alstolarsines A–E (<b>1</b>–<b>5</b>) possessing two unprecedented carbon skeletons of 6/5/5/7/6/6(5) fused polycyclic systems, were isolated from <i>Alstonia scholaris</i>. Their structures were characterized using various methods including spectroscopic data, ECD spectra, and single-crystal X-ray diffraction. The inhibitory activities of alstolarsines A–D (<b>1</b>–<b>4</b>) on DRAK2 phosphorylation and ATP-citrate lyase were evaluated, but all of them were inactive.