Total Syntheses\nof Indole Terpenoids (−)-Lyngbyatoxin,\n(−)-Teleocidin A2, and (−)-7-Geranylindolactam V

A regiodivergent palladium-catalyzed Suzuki–Miyaura\nreaction\nhas been successfully implemented to synthesize (−)-lyngbyatoxin,\n(−)-teleocidin A2, and (−)-7-geranylindolactam V. This\nligand-controlled cross-coupling strategy allowed for the direct preparation\nof these natural products from a single advanced synthetic intermediate,\nproviding the shortest reported route to each compound. Subsequent <i>in vitro</i> studies in cancer cell lines were conducted to\nexplore the chemotherapeutic applications of these natural products.