Ru-Catalyzed Redox-Neutral\nCoupling of <i>N</i>‑Chlorobenzamides with Unsymmetrical\nAlkynes in Water

In water, Ru-catalyzed annulation of <i>N</i>-chlorobenzamides\nwith unsymmetrical internal alkynes bearing aryl, hydroxy, ester,\nand sulfonyl functionalities has been accomplished to afford isoquinolone\nscaffolds under external oxidant-free conditions at room temperature.\nUse of water as reaction medium, redox-neutral conditions, regioselectivity,\nand substrate scope are important practical features.

Publication Details

Journal
Figshare
Published
2024-10-24
DOI
https://doi.org/10.1021/acs.joc.4c02234.s001
Primary Topic
Wheat and Barley Genetics and Pathology
Type
article
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article

Ru-Catalyzed Redox-Neutral\nCoupling of N‑Chlorobenzamides with Unsymmetrical\nAlkynes in Water

Figshare
Wheat and Barley Genetics and Pathology
article

Ru-Catalyzed Redox-Neutral\nCoupling of N‑Chlorobenzamides with Unsymmetrical\nAlkynes in Water

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Abstract

In water, Ru-catalyzed annulation of <i>N</i>-chlorobenzamides\nwith unsymmetrical internal alkynes bearing aryl, hydroxy, ester,\nand sulfonyl functionalities has been accomplished to afford isoquinolone\nscaffolds under external oxidant-free conditions at room temperature.\nUse of water as reaction medium, redox-neutral conditions, regioselectivity,\nand substrate scope are important practical features.

Figshare
Clean water and sanitation
Openalex Percentile: Top 40%
Wheat and Barley Genetics and Pathology
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Ru-Catalyzed Redox-Neutral\nCoupling of <i>N</i>‑Chlorobenzamides with Unsymmetrical\nAlkynes in Water · Figshare (2024) | TGRS Research Map | TGRS