Research on strategies to inhibit CAR-T cell exhaustion

Immunotherapy has achieved good efficacy in clinical anti-tumor therapy， especially chimeric antigen receptor T cell （CAR-T cell） therapy， as an emerging tumor immunotherapy， has achieved breakthrough efficacy in the clinical treatment of hematologic malignancies. However， CAR-T cell face the problem of gradual exhaustion during the treatment process， especially in the treatment of solid tumors， which will lead to poor anti-tumor efficacy and possible risks such as recurrence. This paper analyzed the possible mechanism of CAR-T cell exhaustion and describes the relevant research progress in inhibiting CAR-T cell exhaustion， with a view to designing reasonable therapeutic strategies to reduce CAR-T cell exhaustion and improve the efficacy of CAR-T cell.