One-Step, Catalyst-Free\nContinuous-Flow Method for\nthe Rapid and Safe Synthesis of 1‑Substituted 1<i>H</i>‑Tetrazoles

1-Substituted 1<i>H</i>-tetrazoles are valuable\nbuilding\nblocks in medicinal chemistry; however, their limited synthetic accessibility\nconstrains their use. A new continuous-flow strategy was developed\nto safely obtain tetrazoles from primary amines within minutes. Method\noptimization was aided by theoretical studies leading to different\nconditions depending on the amine structure. The versatility of our\nmethod was demonstrated by using a set of benzylic, aromatic, aliphatic,\nand heteroaromatic amines leading to previously unexplored tetrazoles\nwith satisfactory yields.