Asymmetric Synthesis\nof Taiwaniaquinone H via a Late-Stage\nOxidative Decarboxylation

The asymmetric syntheses of naturally occurring biologically\nrelevant <i>abeo</i>-abietane diterpenoids, (−)-taiwaniaquinone\nG\n(<b>1a</b>), and H (<b>1b</b>) have been reported via\na chiral pool strategy starting from commercially available abietic\nacid. A ring contraction of the middle ring of the [6,6,6]-carbotricyclic\nabietane diterpenoid core was carried out under the Wolff rearrangement.\nFinally, the synthesis of (−)-taiwaniaquinone H (<b>1b</b>) was completed via a one-pot CAN-mediated oxidative decarboxylation.