One-Pot Aminomethylation\nof Heteroarenes by Rongalite\nas <i>In Situ</i> C1 Source

Rongalite-mediated one-pot aminomethylation of heteroarenes\nusing\nsecondary amines/anilines has been developed. This transition-metal-free\nand mild reaction offers an efficient way to synthesize aminomethylated\nheteroaromatic compounds with high yields and broad functional group\ntolerance. Here, Rongalite plays a key role in generating the C1 unit\nsource <i>in situ</i>, which triggers the aminomethylation\nprocess. This approach provides a library of aminomethylated imidazo[1,2-<i>a</i>]pyridines and imidazo[2,1-<i>b</i>]thiazoles.