Amine-Promoted Three-Component\nRadical Selenofunctionalization\nfor the Construction of β‑Hydroxy Selenide Derivatives

An\namine-promoted three-component radical selenofunctionalization\nreaction of alkenes with TBHP and diselenide is disclosed. The reaction\nconditions are mild and suitable for a wide range of substrates (29\nexamples), and all give the corresponding hydroxyselenenylation products\nin moderate to excellent yields. In addition, preliminary studies\non the mechanism reveal that the current method might proceed via\na radical pathway. TBHP serves as both radical initiator and the source\nof hydroxyl group.