Alkaloids and\nStyryl Lactones from <i>Goniothalamus\ntortilipetalus</i> and Their Biological Activities

Phytochemical investigations of the twig and leaf extracts of <i>Goniothalamus tortilipetalus</i> resulted in the isolation and\nidentification of two new alkaloids, goniotortiline (<b>1</b>) and goniotortilactam (<b>2</b>), three new styryl lactone\nderivatives, goniotortilactone (<b>3</b>) and goniotortilols\nA (<b>4</b>) and B (<b>5</b>), and 25 known compounds.\nTheir structures were elucidated by spectroscopic methods and HRESITOFMS\ndata. Compounds <b>5</b>, <b>13</b>, <b>15</b>, <b>16</b>, <b>22</b>, and <b>30</b> inhibited nitric\noxide (NO) production with IC<sub>50</sub> values ranging from 8.7\n± 0.1 to 17 ± 1 μM, revealing stronger effects than\nthe standard drug, dexamethasone (IC<sub>50</sub> 16.9 ± 2.2\nμM), and compound <b>30</b> possessed the most potent\nNO production inhibition. Compounds <b>12</b> and <b>29</b> demonstrated notable efficacy in enhancing glucose consumption with\nIC<sub>50</sub> values of 77 ± 4 and 66 ± 4 μM, respectively,\nwhile their glucose uptakes were 1.7- and 2-fold, respectively.