The Current Development Status in Accelerator Preparation of Radionuclide 68Ge

In recent years，the PET imaging with 68Ga-labeled radiopharmaceuticals have grown significantly，which is driven by the popularity of 68Ge-68Ga generator，the development of targeted tracers，simple labeling procedures，and approval of 68Ga-labeled radiopharmaceuticals. Currently，68Ga is mainly produced by 68Ge-68Ga generator. Therefore，the source and activity of parent nuclide 68Ge become the key factor in the 68Ge-68Ga generator preparation. 68Ge is an artificial radionuclide produced by accelerator，its accelerator preparation is of great significance for promoting the development and application of PET imaging drugs. 68Ge can be often used for the homogenization correction and attenuation correction of the equipment to ensure the accuracy and reliability of PET images，and 68Ge correction source is a key component in the quality control of PET and PET/CT. 68Ge can be prepared by irradiating metal gallium target via proton cyclotron through natGa(p,xn)68Ge or 69Ga(p,2n)68Ge nuclear reaction. This paper summarizes the properties and preparation of 68Ge and introduces the key technologies and research progress of the accelerator production of 68Ge in detail，hoping to provide reference and experience for the preparation of 68Ge and help realize the independent.