Prevention of Isotretinoin-Induced Oxidative Stress and Hepatotoxicity

Isotretinoin, also known as 13-cis-retinoic acid, is one of the most recognized treatments for the skin disease acne vulgaris, which is largely attributed to its high rates of success and overall effectiveness. Isotretinoin treats acne by targeting the skin’s sebum production and limiting it through interactions with retinoic acid and retinoid x receptors. However, the usage of isotretinoin has also become increasingly controversial due to its many side effects, ranging from cheilitis and skin dryness to more serious issues, including hepatotoxicity and birth defects. Thus, it has become vital for researchers to identify these effects and find appropriate methods to reduce the risks. A highly concerning side effect of isotretinoin is its effect of increased oxidative stress and the subsequent emergence of hepatotoxicity, which may be due to isotretinoin’s effects of reducing antioxidant reserves within the body, for example, vitamin E. Possible solutions, including taurine, selenium, and RSV-isotretinoin-SNEEDS, exert antioxidant effects and minimize and prevent isotretinoin-reduced hepatoxicity. Further research to study the effects of isotretinoin and possible solutions to combat its adverse effects can be done to allow for the most effective administration of isotretinoin with minimal consequences.