Preparation and\nWound Repair of Injectable and Self-Healing\nBenzaldehyde-Modified Konjac Glucomannan Oligosaccharide/Polyglutamic\nAcid/ε-Polylysine Hydrogel

Oligosaccharides always have better water solubility,\nhigher possibilities\nfor modification, and unique biofunctions compared with polysaccharides,\nbut they are rarely used as the matrix of a hydrogel. Here, we prepared\na composite BKOS/HPGA/PL hydrogel (BKPP hydrogel) constructed by hydrazone/imine\nbonds between the aldehyde groups of benzaldehyde-modified konjac\nglucomannan oligosaccharide (BKOS) and the primary amino groups of\nboth hydrazide-modified polyglutamic acid (HPGA) and ε-polylysine\n(ε-PL). The hydrogels had both injectable and self-healing properties.\nThe gelation time reached 23 s when 2% of BKOS (DS = 21.7%), 10% HPGA\n(DS = 11.5%), and 10% ε-PL solutions were mixed in a volume\nratio of 5:4.5:0.5. Besides high water-retention capability and good\ncytocompatibility, the hydrogel also maintained both the immunoactivities\nof BKOS and the antibacterial performances of ε-PL and HPGA,\nand thus exhibited good wound healing performance in the whole cortex\nwound repair process of rats, which might have potential for its biomedical\napplication.