A sustainable approach for one-pot, multicomponent synthesis of 2-amino-4H-chromenes using bleach

The present study outlines an efficient and straightforward approach for synthesizing amino-chromenes via multicomponent reaction from aldehyde, dimedone and malononitrile using aqueous sodium hypochlorite (10–13%) (bleach) as a catalyst under neat conditions. Sodium hypochlorite was identified as an effective catalyst, facilitating the reaction with minimal catalyst loading and yielding high product output. The developed protocol demonstrates significant improvements, featuring simplified work-up, reduced energy consumption, shortened reaction times, and an eco-friendly profile with favorable E-factors (3.5), Eco-scale scores (97), and Process mass intensity (6.3).