Research Progress in the Effect and Mechanism of Propolis Polyphenols in Alleviating High Fat Diet-Induced Non-alcoholic Fatty Liver Disease

As dietary habits and the quality of life change, the incidence of non-alcoholic fatty liver disease has increased year by year and has become one of the major public health problems in the world. Due to the complexity of the disease, no drug has been approved for its treatment. Propolis is a natural gelatinous product with extensive pharmacological activities, which can be used in clinical treatment of coronary heart disease, diabetes, hypertension, hyperlipidemia and other diseases. Studies have shown that propolis and its phenolic compounds have pharmacological activities such as hypolipidemic, antioxidant and anti-inflammatory effects, making them promising in alleviating non-alcoholic fatty liver disease. Therefore, this article reviews recent studies on propolis and its phenolic compounds in alleviating non-alcoholic fatty liver disease in order to provide a theoretical reference for research on the alleviative effect of propolis on non-alcoholic fatty liver disease.