Antimicrobial <i>p</i>-terphenyl derivatives from the deep-sea cold seep-derived fungus <i>Aspergillus candidus</i>

Four new <i>p</i>-terphenyl derivatives named phenylcandilides C-F, together with nine known analogues, were isolated from the deep-sea cold-seep-derived fungus <i>Aspergillus candidus</i> HNNU0546. Compounds <b>10</b> and <b>12</b> exhibited antibacterial activity against <i>Staphylococcus aureus</i> with MIC values of 21.6 and 23.6 µM, respectively. Compound <b>5</b> showed antifungal activity with an EC₅₀ value of 3.0 µM against phytopathogenic fungus <i>Alternaria</i> sp., while compound <b>6</b> exhibited inhibitory activity against <i>Curvularia australiensis</i> and <i>Alternaria</i> sp. with the same EC₅₀ values of 3.0 µM, respectively.