EnantioselectivePropargylation and Allenylation ofIsatins Using Chiral Box-Copper/Zinc Catalysts
A method for the asymmetric propargylation and allenylation of isatins catalyzed using chiral Box-copper/zinc catalysts is described. By modulation of the metal and solvent, a series of chiral 3-hydroxy-3-propargyl-2-oxindoles and 3-hydroxy-3-allenyl-2-oxindoles are selectively synthesized in good yields with excellent enantio- and regioselectivities.
Publication Details
- Journal
- Figshare
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1021/acs.joc.4c02850.s001
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00