EnantioselectivePropargylation and Allenylation ofIsatins Using Chiral Box-Copper/Zinc Catalysts

A method for the asymmetric propargylation and allenylation of isatins catalyzed using chiral Box-copper/zinc catalysts is described. By modulation of the metal and solvent, a series of chiral 3-hydroxy-3-propargyl-2-oxindoles and 3-hydroxy-3-allenyl-2-oxindoles are selectively synthesized in good yields with excellent enantio- and regioselectivities.

Publication Details

Journal
Figshare
Published
2025-03-19
DOI
https://doi.org/10.1021/acs.joc.4c02850.s001
Primary Topic
Catalytic Alkyne Reactions
Type
article
Field-Weighted Citation Impact
0.00
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article

EnantioselectivePropargylation and Allenylation ofIsatins Using Chiral Box-Copper/Zinc Catalysts

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Catalytic Alkyne Reactions
article

EnantioselectivePropargylation and Allenylation ofIsatins Using Chiral Box-Copper/Zinc Catalysts

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Abstract

A method for the asymmetric propargylation and allenylation of isatins catalyzed using chiral Box-copper/zinc catalysts is described. By modulation of the metal and solvent, a series of chiral 3-hydroxy-3-propargyl-2-oxindoles and 3-hydroxy-3-allenyl-2-oxindoles are selectively synthesized in good yields with excellent enantio- and regioselectivities.

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Openalex Percentile: Top 53%
Catalytic Alkyne Reactions
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EnantioselectivePropargylation and Allenylation ofIsatins Using Chiral Box-Copper/Zinc Catalysts · Figshare (2025) | TGRS Research Map | TGRS